血清タンパク質

●血漿中には多くの遊離タンパク質が含まれています．これらは血液とともに血管中を移動し，重要な働きをしていると考えられます．しかし，まだ生理的役割が不明なタンパク質が多く存在します．

下の表には通常血液の血漿成分として多い順番にその諸性質を示しています．

●Ｎ−末端アミノ酸は成熟タンパク質について決定されたもの以外はアルブミンのようにブロックされている場合がありますので，電気泳動で分離したスポットについて直接配列分析を行ってもＮ−末端アミノ酸が検出されないことがあります．

●本研究室で扱っているタンパク質については詳しい説明がありますので参照して下さい．


Protein name Amount (mg/ml) pI M.W. Residues Carbohydrate (%) Characteristics N-terminal
Albumin 30-50 4.7 66K 591 0 Binding Capacity Ac-Gly
IgG 8.0-18 5.8-7.3 143-149K 2.9
Haptoglobin 1.7-2.35 4.1 100K 329 16.4 Tetramer
Binds hemoglobin		 Val
IgA 0.9-4.5 - 158-162K 472(a)
227(b)		 7.52 PyroGlu(a)
PyroGlu(b)
IgM 0.6-2.5 - 800-950K 11.8
C8 0..08 - 150K 564(a)
565(b)
182(c)		 - Activation of the complement system Gln(a)
Leu(b)
Gln(c)
Lipoprotein(LDL) 3.5 - 2500K -
Fibrinogen 3 5.8 341K 847(a)
461(b)		 2.8 Polymerize into fibrin Ala(a)
Gln(b)
Transferrin 2.95 5.9 80K 679 5.9 Iron binding transport Val
α1-antitrypsin 2.9 4 54K 394 11.6 Iihibitor of elastase Glu
α2-macroglobulin 2.9 5.4 820K 1451 9.43 Inhibit all four classes of proteases Ser
Lipoprotein(HDL3) 2.25 - - -
C3 1.1 - 185K 1641 2.73 Activation of the complement system Ser
α1-acid glycoprotein 0.9 2.7 44.1K 183 37.9 Modulating immune system Gln
Hemopexin 0.8 4.4-5.0 57K 439 21.9 Binds heme Thr
α2-HS-　glycoprotein 0.6 4.1 49K 349 13.4 Affinity for calcium Ala,Thr
α1-antichymotrypsin 0.45 3.75-4.0 68K 400 24.6 Functions unclear His
Inter-a-trypsin inhibitor 0.45 5.2 160K 884(a)
928(b)
868(c)		 8.4 Carrier of hyaluronan in serum Leu(a)
Phe(b)
Phe(c)
Gc globulin
(Vitamin D-binding protein) 		0.4 4.8 50.8K 458 4.2 Albumin family Leu
Ceruloplasmin 0.35 4.4 132K 1046 7.98 Copper-binding Lys
Fibronectin
(Cold insoluble globulin)		 0.33 - 350K 2355 3.64 Involved in cell adhesion Gln
C4 0.3 - 240K 1725 4.3 Activation of the complement system Lys
Antithrombin 0.29 - 65K 432 13.4 Inhibits thrombin His
Transthyretin
(Prealbumin)		 0.25 4.7 55K 127 0.4 Thyroid hormone-binding Gly
C1 inhibitor 0.24 2.7 1.4K 478 34.7 Serpin family
Activation control of C1 complex 		Asn
C9 0.23 - 79K 538 - Activation of the complement system Gln
α1B-glycoprotein 0.22 4.4-4.6 63K 474 13.3 Function unknown Ala
β2-glycoprotein I
(Apolipoprotein H)		 0.2 5.4 40K 326 18.8 Binds heparin Gly
C1q 0.19 - 410K 223(a)
226(b)
217(c)		 7.81 Component of serum complement system Glu(a)
Gln(b)
Asn(c)
C3 activator 0.18 5.6 60K 5.7
C3 proactivator 0.18 - 80K 10.6
C1s 0.12 - 79K 673 - Activation of the complement system Glu
Plasminogen 0.12 5.6 81K 791 17.1 Convert into plasmin Glu
Prekallikrein 0.103 - 100K 619 - Cleaves Lys-Arg and Arg-Ser bonds Gly
β2-glycoprotein III 0.1 5.1-5.8 35K 10
His-rich 3.8s α2-　glycoprotein 0.09 5.6-6.2 58.5K 507 14.3 Function unknown Val
α1T-gpycoprotein 0.08 - 67K 578 13.7 Albumin family
Probably same as Afamin		 Leu
C5 0.075 - 185K 1658 - Activation of the complement system Gln
C6 0.06 - 125K 913 - Activation of the complement system Cys
C7 0.06 - 120K 821 - Activation of the complement system Ser
9.5s α1-　glycoprotein
(amyloid P-component )		 0.055 5 308K 204 12.8 Interact with DNA and histone His
Zn-α2-　glycoprotein 0.05 3.8 41K 278 18.2 Stimulates lipid degradation PyroGlu
Retinol binding protein 0.045 4.7 21K 183 0 Delivers retinol from liver Glu
Prothrombin 0.006 - 72K 598 11.7 Thrombin cleaves bonds after Arg and Lys Gln
Transcortin 0.004 - 55.7K 383 15.5 Transport protein for glucocorticoids Met
8s α3-glycoprotein 0.004 4.2-4.6 220K 31.4