Original article

(1) Sano H, Nagai R, Matsumoto K, Horiuchi S: Receptor for proteins modified by advanced glycation endproducts (AGE) their functional role in atherosclerosis. Mechanisms of Aging and Development, 1999, 107: 333-346

(2) Ohgami N, Nagai R, Ikemoto M, Arai H, Kuniyasu A, Horiuchi S, Nakayama H. CD36, a member of class B scavenger receptor family, is a receptor for advanced glycation end products. Ann N Y Acad Sci. 2001, 947: 350-355

(3) Ohgami N, Nagai R, Ikemoto M, Arai H, Miyazaki A, Hakamata H, Horiuchi S, Nakayama H. CD36, serves as a receptor for advanced glycation endproducts (AGE). J Diabetes Complications. 2002, 16: 56-59

(4) Nagai R, Horiuchi S, Application of monoclonal antibody libraries for the measurement of glycation adducts, Biochemical Society Transactions, 2003, 31: 1438-1440

(5) Nagai R, Accumulation of Advanced Glycation End Products in Age-dependent Disorders. Med. Hypotheses Res. 2004, 1: 159-168

(6) Naito Y, Lee Masaichi-Chang, Kato Y, Nagai R and Yonei Y. Oxidative stress. Anti-Aging Medicine 7 (5) : 36-44, 2010

(7) Nakano M and Nagai R. Heat treatment increases the level of AGEs in human blood. Anti-Aging Medicine, 7(8): 92-93, 2010

(8) Nagai R, Mori T, Yamamoto Y, Kaji Y, Yonei Y. Significance of Advanced Glycation End Products in Aging-Related Disease. Anti-Aging Medicine 7 (10) : 112-119, 2010

(9) Miyazawa T, Nakagawa K, Shimasaki S, Nagai R. Lipid glycation and protein glycation in diabetes and atherosclerosis. Amino Acids. 42(4):1163-1170, 2012

(10) Nagai R, Murray DB, Metz TO, Baynes JW. Chelation: A fundamental mechanism of action of AGE inhibitors, AGE breaker, and other inhibitors of diabetes complications. Diabetes, 61(3):549-59, 2012

(11) Nagai R, Jinno M, Ichihashi M, Koyama H, Yamamoto Y, Yonei Y. Advanced Glycation End Products and Their Receptors as Risk Factors for Aging. Anti-Aging Medicine 9 (4) : 108-113, 2012

(12) Nagai R, Shirakawa J, Ohno R, Moroishi N, Nagai M. Inhibition of AGEs formation by natural products. Amino Acids. 46(2):261-266, 2014

(13) Nagai R, Shirakawa J, Fujiwara Y, Ohno R, Moroishi N, Sakata N, Nagai M. Detection of AGEs as markers for carbohydrate metabolism and protein denaturation. J Clin Biochem Nutr. 55(1):1-6, 2014

(14)Nagai R, Shirakawa JI, Ohno RI, Hatano K, Sugawa H, Arakawa S, Ichimaru K, Kinoshita S, Sakata N, Nagai M. Antibody-based detection of advanced glycation end-products: promises vs. limitations. Glycoconj J. 33(4):545-552, 2016

(1) Toriumi K, Iino K, Ozawa A, Miyashita M, Yamasaki S, Suzuki K, Sugawa H, Tabata K, Yamaguchi S, Usami S, Itokawa M, Nishida A, Nagai R, Kamiguchi H, Arai M. Glucuronic acid is a novel source of pentosidine, associated with schizophrenia., Redox Biol (2023) 67: 102876.

(2) Katsuta N, Nagai M, Nagai R. Mass spectrometric and immunological evaluation of AGEs during incubation of ribose with gelatin. Glycative stress Res. 10(1) 16-26, 2023

(3) Tominaga Y, Katogi T, Hoshi Y, Nagai R. Light-emitting diode-induced ellagic acid production in Drosera tokaiensis inhibits advanced glycation end-product formation. Biocatal Agric Biotechnol. In press

(4)Tominaga Y, Katogi T, Funakoshi S, Mimura A, Nakano S, Nagai R, Hoshi Y, Effects of genome composition on phenotypic plasticity and secondary metabolites in the amphidiploid species Drosera tokaiensis and its parent species under different monochromatic lighting. Cytologia volume 88 issue 4 2023, In press.

(5)Yamaguchi H, Matsumura T, Sugawa H, Niimi N, Sango K, Nagai R. Glucoselysine, a unique advanced glycation end-product of the polyol pathway and its association with vascular complications in type 2 diabetes. J Biol Chem. (2024): 300(7):107479

(6)Kato S, Matsumura T, Sugawa H, Nagai R. Correlation between serum advanced glycation end-products and vascular complications in patient with type 2 diabetes. Sci Rep. 14(1):18722, 2024

(7)Sugawa H, Ikeda T, Tominaga Y, Katsuta N, Nagai R. Rapid formation of N ε-(carboxymethyl)lysine (CML) from ribose depends on glyoxal production by oxidation. RSC Chem Biol. 2024, in press

(1) Masao Jinno, Ryoji Nagai, Masayoshi Takeuchi, Aiko Watanabe, Koji Teruya, Hikari Sugawa, Naohisa Hatakeyama, Yuichi Jinno. Trapa bispinosa Roxb. extract lowers advanced glycation end-products and increases live births in older patients with assisted reproductive technology: a randomized controlled trial. Reprod Biol Endocrinol. 19(1):149, 2021. IF 3.498

(2) Ikuho Ban、 Shiori Sakake、 Naoto Kushida、 Noriyoshi Manabe、 Yoshiki Yamaguchi、 Ryoji Nagai、Identification of acetaldehyde-modified lysine ,Glycative Stress Research 8 (4): 201-210, 202, 2021

(3) Ban I, Sugawa H, Nagai R, Protein modification with ribose generates MG-H1, Int J Mol Sci. 23(3):1224, 2022

(4) Sayuri Kato, Ryoji Nagai , Conventional evaluation of glycation with plate reader and its correlation with CML formation, Glycative Stress Research, 8 (4), 171-174, 2021

(5) Katsuta N, Takahashi H, Nagai M, Sugawa H, Nagai R,Changes in S-(2-succinyl)cysteine and advanced glycation end-products levels in mouse tissues associated with aging, Amino Acids, 54, 653-661, 2022.

(6)Kato S, Sugawa H, Tabe K, Ito K, Nakashima H, Nagai R, Rapid pretreatment for multi-sample analysis of advanced glycation end products and their role in nephropathy, J Clin Biochem Nutr. 70(3):256-261, 2022

(7) Itakura M, Yamaguchi K, Kitazawa R, Lim SY, Anan Y, Yoshitake J, Shibata T, Negishi L, Sugawa H, Nagai R, Uchida K. Histone functions as a cell-surface receptor for AGEs. Nat Commun. 13(1):2974, 2022.

(8)Katsuta N, Nagai M, Saruwatari K, Nakamura M, Nagai R. Mitochondrial stress and glycoxidation increase with decreased kidney function. J Clin Biochem Nutr. In press

(9)Osonoi S, Mizukami H, Takeuchi Y, Sugawa H, Ogasawara S, Takaku S, Sasaki T, Kudoh K, Ito K, Sango K, Nagai R, Yamamoto Y, Daimon M, Yamamoto H, Yagihashi S. RAGE activation in macrophages and development of experimental diabetic polyneuropathy. JCI Insight. 2022 Dec 8;7(23):e160555, 2022

(10)Nakashima Y, Yamamoto N, Tsukioka R, Sugawa H, Ohshima R, Aoki K, Hibi T, Onuki K, Fukuchi Y, Yasuda S, Nagai R, Kinoshita H. In vitro evaluation of the anti-diabetic potential of soymilk yogurt and identification of inhibitory compounds on the formation of advanced glycation end-products. Food Bioscience Volume 50, Part A, December 2022,

(1) Kinoshita S, Mera K, Ichikawa H, Shimasaki S, Nagai M, Taga Y, Iijima K, Hattori S, Fujiwara Y, Shirakawa J, Nagai R. N^ω-(carboxymethyl)arginine is one of the dominant advanced glycation end-products in glycated collagens and mouse tissues. Oxid Med Cell Longev. PMID: 31583049 PMCID: PMC6754957 DOI: 10.1155/2019/9073451, 2019

(2) Kinoshita S, Sugawa H, Nanri T, Ohno R, Shirakawa J, Sato H, Katsuta N, Sakake S, Nagai R. Trapa bispinosa Roxb and lutein ameliorate cataract in type 1 diabetic rats. J Clin Biochem Nutr. 66(1): 8-14, 2019

(3) Kashiwabara S, Hosoe H, Ohno R, Nagai R, Shiraki M. Development and evaluation of novel ELISA for determination of urinary pentosidine. J Nutr Sci Vitaminol (Tokyo) 65, 526-533, 2019

(4) Ohno R, Ichimaru K, Tanaka S, Sugawa H, Katsuta N, Sakake S, Tominaga Y, Ban I, Shirakawa J, Yamaguchi Y, Ito E, Taniguchi N, Nagai R. Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats. J. Biol. Chem. 294(46):17326-17338, 2019

(5) Suzuki R, Fujiwara Y, Saito M, Arakawa S, Shirakawa J, Yamanaka M, Komohara Y, Marumo K, Nagai R.Intracellular Accumulation of Advanced Glycation End-Products Induces Osteoblast Apoptosis via Endoplasmic Reticulum Stress. J Bone Miner Res.PMID: 32427355.DOI: 10.1002/jbmr.4053, 2020

(6) Tominaga Y, Sugawa H, Hirabayashi K, Ikeda T, Hoshi Y, Nagai R.Drosera tokaiensis extract containing multiple phenolic compounds inhibits the formation of advanced glycation end-products.Arch Biochem Biophys.PMID: 32941804.DOI: 10.1016/j.abb.2020.108586, 2020

(1) Ito K, Sakata N, Nagai R, Shirakawa JI, Watanabe M, Mimata A, Abe Y, Yasuno T, Sasatomi Y, Miyake K, Ueki N, Hamauchi A, Nakashima H. High serum level of methylglyoxal-derived AGE, Nδ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine, independently relates to renal dysfunction. Clin Exp Nephrol. 21(3): 398-406, 2017

(2) Eto A, Sakata N, Nagai R, Shirakawa JI, Inoue R, Kiyomi F, Nii K, Aikawa H, Iko M, Tsutsumi M, Sakamoto K, Hiraoka F, Mitsutake T, Hanada H, Kazekawa K. N^ε(carboxymethyl)lysine concentration in debris from carotid artery stenting correlates independently with signal intensity on T1-weighted black-blood magnetic resonance images. J Stroke Cerebrovasc Dis. 26(6):1341-1348, 2017

(3) Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H. Contribution of methylglyoxal to delayed healing of bone injury in diabetes. Mol Med Rep 16(1): 403-409, 2017

(4) Matsuda S, Sugawa H, Shirakawa J, Ohno R, Kinoshita S, Ichimaru K, Arakawa S, Nagai M, Kabata K, Nagai R. Aphanothece sacrum (Sur.) Okada prevents cataractogenesis in type 1 diabetic mice. J Nutr Sci Vitaminol (Tokyo) 63(4):263-268, 2017

(5) Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration. Proc Natl Acad Sci USA 114(22): E4472-E4481, 2017

(6) Kinoshita S, Furusawa C, Sugawa H, Shirakawa J, Ohno R, Ichimaru K, Nagai M, Nagai R. Inhibitory effect of natural products on the formation of advance glycation end products. Glycative Stress Research 4 (2): 109-116, 2017

(7)Maejima K, Ohno R, Nagai R, Nakata S, Effect of mangosteen pericarp extract on skin moisture and arterial stiffness: Placebo-controlled double-blinded randomized clinical trial, Glycative Stress Research, 5 (2), 095-103, Apr, 2018

(1) Ohno R, Moroishi N, Maejima K, Saigusa M, Yamanaka M, Nagai M, Yoshimura M, Amakura Y, Nagai R, Mangosteen pericarp extract inhibits the formation of pentosidine and ameliorates skin elasticity, J Clin Biochem Nutr. 57(1):27-32, 2015

(2) Shibuya T, Kaburagi T, Nagai R, Oshiro S, The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake, J Clin Biochem Nutr. 57(1):44-49, 2015

(3) Nakashima K, Miyashita H, Yoshimitsu H, Fujiwara Y, Nagai R, Ikeda T. Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products. J Nat Med. 70(2):290-295, 2016

(4) Yamanaka M, Matsumura T, Ohno R, Fujiwara Y, Shinagawa M, Sugawa H, Hatano K, Shirakawa J, Kinoshita H, Ito K, Sakata N, Araki E, Nagai R, Non-invasive measurement of skin autofluorescence to evaluate diabetic complications, J Clin Biochem Nutr. 58 (2), 135-140, 2016

(5) Yamanaka M, Shirakawa J, Ohno R, Shinagawa M, Hatano K, Sugawa H, Arakawa S, Furusawa C, Nagai M, Nagai R, Soft-shelled turtle eggs inhibit the formation of AGEs in the serum and skin of diabetic rats, J Clin Biochem Nutr. 58 (2), 130-134, 2016

(6) Sugawa H, Ohno R, Shirakawa J, Nakajima A, Kanagawa A, Hirata T, Ikeda T, Moroishi N, Nagai M and Nagai R, Eucommia ulmoides extracts prevent the formation of advanced glycation end products, Food Funct, 7(6):2566-2573, 2016

(7) Shirakawa J, Arakawa S, Tagawa T, Gotoh K, Oikawa N, Ohno R, Shinagawa M, Hatano K, Sugawa H, Ichimaru K, Kinoshita S, Furusawa C, Yamanaka M, Kobayashi M, Masuda S, Nagai M, Nagai R, Salacia chinensis L. extract ameliorates abnormal glucose metabolism and improves the bone strength and accumulation of AGEs in type 1 diabetic rats, Food Funct, 7(6):2508-2515, 2016

(1) Moore CJ, Shao CH, Nagai R, Kutty S, Singh J, Bidasee KR. Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes. Mol Cell Biochem. 376(1-2):121-135, 2013

(2) Nakano M, Kubota M, Owada S, Nagai R. The pentosidine concentration in human blood specimens is affected by heating. Amino Acids. 44(6):1451-1456, 2013

(3) Heilmann M, Wellner A, Gadermaier G, Ilchmann A, Briza P, Krause M, Nagai R, Burgdorf S, Scheurer S, Vieths S, Henle T, Toda M. Ovalbumin modified with pyrraline, a Maillard reaction product, shows enhanced T-cell immunogenicity. J Biol Chem. 289(11):7919-7928, 2014

(4) Jo-Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, Shirakawa J, Nagai R, Miyata T, Nagano T, Hirata Y, Inagi R, Nangaku M. Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation. Aging Cell, 13(3):519-528, 2014

(1) Hirose J, Yamabe S, Takada K, Okamoto N, Nagai R, Mizuta H. Immunohistochemical distribution of advanced glycation end products (AGEs) in human osteoarthritic cartilage. Acta histochemica. 113(6):613-618, 2011

(2) Curtis TM, Hamilton R, Yong P-H, McVicar CM, Berner A, Pringle R, Uchida K, Nagai R, Brockbank S, Stitt SW. Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products. Diabetologia 54(3):690-698, 2011

(3) Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shimoi M, Maruyama Y, Takeishi Y. Involvement of membrane type-1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways. J. Cell. Physiol. 226(6):1554-1563, 2011

(4) Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R. Natural Compounds Containing a Catechol Group Enhance the Formation of Ne-(carboxymethyl)lysine of the Maillard Reaction. Free Radic. Biol. Med. 50(7): 883-891, 2011

(5) Toyokuni S, Hirao A, Wada T, Nagai R, Date A, Yoshii T, Akatsuka S, Yamashita Y, Kawada A. Age- and sun exposure-dependent differences in 8-hydroxy-2’-deoxyguanosine and Ne-(carboxymethyl)lysine in human epidermis. J. Clin. Biochem. Nutr. 49(2):121-124, 2011

(6) Katsumata A, Kimura M, Saigo H, Aburaya K, Nakano M, Ikeda T, Fujiwara Y, Nagai R. Changes in Esculeoside A content in different regions of the tomato fruit during maturation, and heat processing. J. Agric. Food Chem. 59(8):4104-10, 2011

(7) Mera K, Nagai R, Takeo K, Izumi M, Maruyama T, Otagiri M. An autoantibody Against Ne-(carboxyethyl)lysine (CEL): Possible Involvement in the Removal of CEL-Modified Proteins by Macrophages. Biochem. Biophys. Res. Commun. 407(2):420-425, 2011

(8) Park J, Kwon MK, Huh JY, Choi WJ, Jeong LS, Nagai R, Kim WY, Kim J, Lee TG, Lee HB, Ha H. Renoprotective antioxidant effect of alagebrium in experimental diabetes. Nephrol Dial. Transplant. 26(11):3474-3484, 2011

(9) Fujiwara Y, Hayashida A, Tsurushima K, Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, Ikeda T. Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. J. Agric. Food Chem. 59(9): 4544-4552, 2011

(10) Shao CH, Capek HL, Patel KP, Wang M, Tang K, DeSouza C, Nagai R, Mayhan W, Periasamy M, Bidasee KR. Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes. Diabetes. 60(3):947-59, 2011

(11) Mori Y, Aki K, Kuge K, Tajima S, Yamanaka N, Kaji Y, Yamamoto N, Nagai R, Yoshii H, Fujii N, Watanabe M, Kinouchi T and Fujii N. UV B-irradiation enhances the racemization and isomerizaiton of aspartyl residues and production of Ne-carboxymethyl lysine (CML) in keratin of skin. J Chromatogr B Analyt Technol Biomed Life Sci. 879(29):3303-3309, 2011

(12) Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M. Glyoxalase-I retards renal senescence. Am J Pathol. 179(6):2810-2821, 2011

(13) Shimasaki S, Kubota M, Yoshitomi M, Takagi K, Suda K, Mera K, Fujiwara Y, Nagai R. Nω-(carboxymethyl)arginine Accumulates in Glycated Collagen and Klotho-deficient Mouse Skin. Anti-Aging Medicine 8 (6) : 82-87, 2011

(14) Nakano M, Kubota M, Owada S, Nagai R. The pentosidine concentration in human blood specimens is affected by heating. Amino Acids. In press [Epub ahead of print]

(15) Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, Nagai R. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting ACAT. J Agric Food Chem. 60(10):2472-2479, 2012

(16) Yoshinaga E, Kawada A, Ono K, Fujimoto E, Wachi H, Harumiya S, Nagai R, Tajima S. Ne-(Carboxymethyl)lysine Modification of Elastin Alters Its Biological Properties: Implications for the Accumulation of Abnormal Elastic Fibers in Actinic Elastosis. J Invest Dermatol. 132(2):315-323, 2012

(17) Nagai R, Murray DB, Metz TO, Baynes JW. Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications. Diabetes. 61(3):549-559, 2012

(18) Andrades ME, Lorenzi R, Nagai R, Moreira JCF, Ritter C, Dal-Pizzol F. Plasma glycation levels are associated with severity and outcomes in septic patients. Eur J Clin Invest. In press

(19) Shao C, Tian C, Ouyang S, Caronda Moore C, Fadhel Alomar F, Nemet I, D’Souza A, Nagai R, Kutty S, Rozanski GJ, Ramanadham S, Singh J, Bidasee K. Carbonylation Induces Heterogeneity in Cardiac Ryanodine Receptors (RyR2) Function During Diabetes. Mol Pharmacol, in press

(1) Glenn JV., Mahaffy H., Wu K., Smith G., Nagai R., Simpson DAC., Boulton ME., Stitt AW. AGE-modified substrate induces global gene expression changes in ARPE-19 monolayers: relevance to lysosomal dysfunction and lipofuscin accumulation. Invest. Ophth. Vis. Sci. 50, 441-451 2009

(2) Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Suda T, Oike Y, Araki E. Angptl 4 Deficiency Improves Lipid Metabolism, Suppresses Foam Cell Formation and Protects Against Atherosclerosis. Biochem. Biophys. Res. Commun. 20, 379(4):806-811, 2009

(3) Kumagai T, Nangaku M, Kojima I, Nagai R, Ingelfinger JR, Miyata T, Fujita T, Inagi R. Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats. Am J Physiol Renal Physiol. 296(4): F912-921, 2009

(4) Matsumoto K, Fujiwara Y, Nagai R, Yoshida M. Immunohistochemical detection of advanced glycation end products in human bladder with specific monoclonal antibody. Int J Urol.16: 402-405, 2009

(5) Frizzell N, Rajesh M, Jepson MJ, Nagai R, Carson JA, Thorpe SR, Baynes JW. Succination* of thiol groups in adipose tissue proteins in diabetes:Succination inhibits polymerizaton and secretion of adiponectin. J Biol Chem. 284, 25772-25781, 2009

(6) Fujimoto E, Kobayashi T, Fujimoto N, Akiyama M, Tajima S, Nagai R. AGE-modified collagen I and III induce keratinocyte terminal differentiation through AGE receptor (CD36): Epidermal-dermal interaction in acquired perforating dermatosis. J. Invest. Dermatol. 130 (2): 405-414, 2009

(7) Motomura K, Fujiwara Y, Kiyota N, Tsurushima K, Takeya M, Nohara T, Nagai R, Ikeda T. Astragalosides Isolated from the Root of Astragalus Radix Inhibits the Formation of Advanced Glycation End-products. J. Agric. Food Chem. 57 (17): 7666-7672, 2009

(8) Mera K, Takeo K, Izumi M, Maruyama T, Nagai R, Otagiri M. Effect of Reactive-Aldehydes on the Modification and Dysfunction of Human Serum Albumin. J. Pharm. Sci. 99 (3) 1614-1625, 2009

(9) Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M. Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity: the role of macrophage scavenger receptor class A type I and II, J Allergy Clin Immunol. 125(1): 175-183, 2010

(10) Kamioka M, Ishibashi T, Sugimoto K, Uekita H, Nagai R, Sakamoto N, Ando K, Ohkawara H, Teramoto T, Maruyama Yand Takeishi Y. Blockade of Renin-Angiotensin System Attenuates Advanced Glycation End Products-Mediated Signaling Pathways. J Atheroscler Thromb. 17(6): 590-600, 2010

(11) Nagai R, Nagai M, Shimasaki S, Baynes JW, Fujiwara Y. Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type1) diabetic rats. Biochem. Biophys. Res. Commun. 393, 118-122, 2010

(12) Ye X, Ng T. B. Nagai R. Inhibitory effect of fermentation byproducts on formation of advanced glycation end-products. Food Chem. 121, 1039-1045, 2010

(13) Lai YL, Aoyama S, Nagai R, Miyoshi N, Ohshima H. Inhibition of L-arginine metabolizing enzymes by L-arginine-derived advanced glycation end products. J Clin Biochem Nutr. 46(2):177-185, 2010

(14) Lorenzi R, Andrades ME, Bortolin RC, Nagai R, Dal-Pizzol F, Moreira JF. Glycolaldehyde Induces Oxidative Stress in the Heart: A Clue to Diabetic Cardiomyopathy? Cardiovasc Toxicol. 10(4):244-249, 2010

(15) Lorenzi R, Andrades ME, Bortolin RC, Nagai R, Dal-Pizzol F, Moreira JF. Circulating Glycolaldehyde Induces Oxidative Damage in the Kidney of Rat. Diabetes Research and Clinical Practice. Vol 89,262-267, 2010

(1) Kaji Y., Nagai R., Amano S., Takazawa Y., Fukayama M., Oshika T. Advanced glycation end product deposits in climatic droplet keratopathy. Br J Ophthalmol. 91, 85-88 2007

(2) Kobayashi S., Nomura M., Nishioka T., Kikuchi M., Ishihara A., Nagai R., Hagino N. Overproduction of Ne-(Carboxymethyl)lysine-Induced Neovascularization in Cultured Choroidal Explant of Aged Rat. Biol Pharm Bull. 30,133-138 2007

(3) Nagai R., Fujiwara Y., Mera K., Otagiri M. Investigation of pathways of AGEs accumulation in macrophages. Mol. Nutr. Food Res. 51, 462-467 2007

(4) Mera K., Nagai R., Haraguchi N., Fujiwara Y., Araki T., Sakata N., Otagiri M. Hypochlorous acid generates Ne-(carboxymethyl)lysine from Amadori products. Free Radic. Res. 41, 713-718 2007

(5) Kanayama M., Yamaguchi S., Shibata T., Shibata N., Kobayashi M., Nagai R., Arai H., Takahashi K., and Uchida K. Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal. J. Biol. Chem. 282, 24166-24174 2007

(6) Fujiwara Y., Kiyota N., Hori M., Matsushita S., Iijima Y., Aoki K., Shibata D., Takeya M., Ikeda T., Nohara T and Nagai R. Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting ACAT. Arterioscler Thromb Vasc Biol. 27, 2400-2406 2007

(7) Nagai R., Brock JW., Blatnik M., Baatz JE., Bethard J., Walla MD., Thorpe SR., Baynes JW., Frizzell N. Succination of protein thiols during adipocyte maturation – a biomarker of mitochondrial stress. J Biol Chem. 282, 34219-34228 2007

(8) Nagai R., Mera K, Nakajou K., Fujiwara Y., Iwao Y., Imai H., Murata T and Otagiri M. The ligand activity of AGE-proteins to scavenger receptors is dependent on their rate of modification by AGEs. Biochim Biophys Acta – Molecular Basis of Disease. 1772, 1192-1198 2007

(9) Kim HY., Kang KS., Yamabe N., Nagai R and Yokozawa T. Protective effect of heat-Processed American ginseng against diabetic renal damage in rats. J. Agric. Food Chem. 55: 8491-8497, 2007

(10) Waanders F., van den Berg E., Nagai R., van Veen I., Navis G and van Goor H. Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats. Nephrol. Dial. Transplant. 23, 518-524 2008

(11) Matsumoto K., Fujiwara Y., Nagai R., Yoshida M., Ueda S. Expression of two isozymes of acyl-coenzyme A: Cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma. Int. J. Urol. 15, 166-170 2008

(12) Nagai R., Fujiwara Y., Mera K., Yamagata K., Sakashita N., Takeya M. Immunochemical detection of N (carboxyethyl)lysine using a specific antibody. J. Immunol. Methods 332, 112-120 2008

(13) Kakehashi A., Inoda S., Mameuda C., Kuroki M., Jono T., Nagai R., Horiuchi S, Kawakami M, Kanazawa Y. Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy. Diabetes Res Clin Pract. 79, 438-445 2008

(14) Nagai R., Fujiwara Y., Mera K., Motomura K., Iwao Y., Tsurushima K., Nagai M., Takeo K., Yoshitomi M., Otagiri M and Ikeda T. Usefulness of antibodies for evaluating the biological significance of AGEs. Ann N Y Acad Sci. 1126, 38-41 2008

(15) Nagai R., Mera K., Fujiwara Y., Nagai M., Otagiri M. Comparison of Pharmacokinetics Between Highly- and Mildly-modified AGE-proteins in Mice. Ann N Y Acad Sci. 1126, 325-327 2008

(16) Mera K., Fujiwara Y., Otagiri M., Sakata N., Nagai R. Immunological Detection of Nw-carboxymethylarginine by Specific Antibody. Ann N Y Acad Sci. 1126, 155-157 2008

(17) Fujiwara Y., Kiyota N., Motomura K., Mera K., Takeya M., Ikeda T., Nagai R. Some Natural Compounds Enhance CML Formation. Ann N Y Acad Sci. 1126, 152-154 2008

(18) Mera K., Nagai M., Brock JW., Fujiwara Y., Imai H., Murata T., Maruyama T., Baynes JW., Otagiri M., Nagai R. Glutaraldehyde is an Effective Cross-linker for Production of Antibodies Against Advanced Glycation End Products. J. Immunol. Methods 334 (1-2), 82-90 2008

(19) Guo ZJ., Niu HX., Hou FF., Zhang L., Fu N., Nagai R., Lu X., Chen BH., Shan YX., Tian JW., Nagaraj RH., Xie D., Zhang X. Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway. Antioxid Redox Signal. 10, 1699-1712 2008

(20) Iwao Y, Nakajou K, Nagai R, Kitamura K, Anraku M, Maruyama T, Otagiri M. CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products. Am J Physiol Renal Physiol. 295, F1871-F1880, 2008

(1) Morita K., Urabe K., Moroi Y., Koga T., Nagai R., Horiuchi S., Furue M. Migration of keratinocytes is impaired on glycated collagen I. Wound Repair Regen. 13, 93-101 2005

(2) Greven WL., Waanders F., Nagai R., Heuvel MC., Navis G., Goor H. Mesangial Accumulation of GA-pyridine, a Novel Glycolaldehyde-derived AGE, in Human Renal Disease. Kid Int. 68, 595-602 2005

(3) Waanders F., Greven WL., Baynes JW., Thorpe SR., Kramer AB., Nagai R., Sakata N., Goor H., Navis G. Renal Accumulation of Pentosidine in Non-Diabetic Proteinuria-Induced Renal Damage in Rats. Nephrol. Dial. Trans. 20, 2060-2070 2005

(4) Nagai R., Deemer EK., Brock JW., Thorpe SR., Baynes JW, Effect of glucose concentration on formation of AGEs in erythrocytes in vitro. Ann. NY Acad. Sci. 1043, 146-150 2005

(5) Matsunaga N., Anan I., Rosenberg P., Nagai R., Lundstrom O., Horiuchi S., Ando Y., Suhr OB. Advanced glycation end product is implicated in amyloid-related kidney complications. Scand. J. Clin. Lab. Invest. 65, 263-271 2005

(6) Unno Y., Sakai M., Sakamoto Y., Kuniyasu A., Nagai R., Nakayama H., Horiuchi S. Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway. Ann N Y Acad Sci. 1043, 696-701 2005

(7) Horiuchi S., Unno Y., Usui H., Shikata K., Takaki K., Koito W., Sakamoto Y., Nagai R., Makino K., Sasao A., Wada J., Makino H. Pathological roles of advanced glycation end product receptors SR-A and CD36. Ann N Y Acad Sci. 1043, 671-675 2005

(8) Liu SX., Hou FF., Guo ZJ., Nagai R., Zhang WR., Liu ZQ., Zhou ZM., Zhou M., Xie D., Wang GB., Zhang X. Advanced Oxidation Protein Products Accelerate Atherosclerosis Through Promoting Oxidative Stress and Inflammation. Arterioscler Thromb Vasc Biol. 26, 1156-1162, 2006

(9) Alderson NL., Wang Y., Blatnik M., Frizzell N., Walla MD., Lyons TJ., Alt N., Carson JA., Nagai R., Thorpe SR., Baynes JW. S-(2-succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate. Arch Biochem Biophys. 450, 1-8 2006

(10) Nakano N., Fukuhara-Takaki K., Jono T., Nakajou K., Eto N., Horiuchi S., Takeya M., Nagai R. Association of advanced glycation end products to A549 cells, a human pulmonary epithelial cell line, is mediated by a receptor distinct from scavenger receptor family and RAGE. J Biochem. 139, 821-829 2006

(11) Kang KS., Kim HY., Yamabe N., Nagai R., Yokozawa T. Protective Effect of Sun Ginseng against Diabetic Renal Damage. Biol Pharm Bull. 8, 1678-1684 2006

(12) Kato M., Kato S., Horiuchi S., Nagai R., Horie Y., Hayashi K. Mallory bodies in hepatocytes of alcoholic liver disease and primary biliary cirrhosis contain Ne-(carboxymethyl)lysine-modified cytokeratin, but not those in hepatic carcinoma cells. Yonago Acta medica. 49, 83-92 2006

(1) Kaji .Y, Amano S., Usui T., Oshika T., Yamashiro K., Ishida S., Suzuki K., Tanaka S., Adamis AP., Nagai R., Horiuchi S. Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells. Invest Ophthalmol Vis Sci. 44:521-528 2003

(2) Nagai R., Araki T., Hayashi CM., Hayase F., Horiuchi S.. Identification of Ne-(carboxyethyl)lysine, one of the methylglyoxal-derived AGE structures, in glucose-modified protein: mechanism for protein modification by reactive aldehydes. J Chromatogr B Analyt Technol Biomed Life Sci. 788, 75-84 2003

(3) Saito A., Nagai R., Tanuma A., Hama H., Cho K., Takeda T., Yoshida Y., Toda T., Shimizu F., Horiuchi S., Gejyo F. Role of megalin in endocytosis of advanced glycation end products: implications for a novel protein binding to both megalin and advanced glycation end products. J Am Soc Nephrol. 14, 1123-1131 2003

(4) Sakata N., Noma A., Yamamoto Y., Okamoto K., Meng J., Takebayashi S., Nagai R., Horiuchi S. Modification of elastin by pentosidine is associated with the calcification of aortic media in patients with end-stage renal disease. Nephrol Dial Transplant. 18, 1601-1609 2003

(5) Svistounov DN., Berg TJ, McCourt PA., Zykova SN., Elvevold KH., Nagai R., Horiuchi S., Smedsrod BH. Lack of recognition of Ne-(carboxymethyl)lysine by the mouse liver reticulo-endothelial system: implications for pathophysiology. Biochem Biophys Res Commun. 309, 786-791 2003

(6) Sakata N., Takeuchi K., Noda K., Saku K., Tachikawa Y., Tashiro T., Nagai R., Horiuchi S.. Calcification of the Medial Layer of the Internal Thoracic Artery in Diabetic Patients: Relevance of Glycoxidation. J Vasc Res. 40, 567-574 2004

(7) Moh A., Sakata N., Takebayashi S., Tateishi K., Nagai R., Horiuchi S., Chihara J.. Increased production of urea hydrogen peroxide from Maillard reaction and a UHP-Fenton pathway related to glycoxidation damage in chronic renal failure. J Am Soc Nephrol. 4, 1077-1085 2004

(8) Hagino N., Kobayashi S., Tsutsumi T., Horiuchi S., Nagai R., Setalo G., Dettrich E. Vascular change of hippocampal capillary is associated with vascular change of retinal capillary in aging. Brain Res Bull. 62, 537-547 2004

(9) Alt N., Carson JA., Alderson NL., Wang Y., Nagai R., Henle T., Thorpe SR., Baynes JW. Chemical modification of muscle protein in diabetes. Arch Biochem Biophys. 425, 200-206 2004

(10) Kobayashi S., Shinohara H., Tsuneki H., Nagai R., Horiuchi S. Ne-(Carboxymethyl)lysine Proliferated CD34(+) cells from rat choroidal explant in culture. Biol Pharm Bull. 27, 1382-1387 2004

(11) Jono T., Nagai R., Lin X., Ahmed N., Thornalley PJ., Takeya M., Horiuchi S. Ne-(carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone. J Biochem. 136, 351-358 2004

(12) Kobayashi S., Suzuki M., Tsuneki H., Nagai R., Horiuchi S., Hagino N. Overproduction of Ne-(Carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of streptozotocin-diabetic Rat. Biol Pharm Bull. 27, 1565-1571 2004

(13) Unno Y., Sakai M., Sakamoto Y., Kuniyasu A., Nakayama H., Nagai R., Horiuchi S. Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36. Biochem Biophys Res Commun 325, 151-156 2004

(14) Koito W., Araki T., Horiuchi S., Nagai R. Conventional antibody against Ne-(Carboxymethyl)lysine (CML) shows cross-reaction to Ne-(Carboxyethyl)lysine (CEL): Immunochemical quantification of CML with a specific antibody. J Biochem. 136, 831-837 2004

(1) Ohgami N., Nagai R., Ikemoto M., Arai H., Kuniyasu A., Horiuchi S., Nakayama H: CD36, a member of class B scavenger receptor family, as a receptor for advanced glycation end products (AGE). J. Biol. Chem. 276, 3195-3202 2001

(2) Amano S., Kaji Y., Oshika T., Oka T., Machinami R., Nagai R., Horiuchi S: Advanced glycation end products in human optic nerve head. Br J Ophthalmol. 85, 52-55 2001

(3) Zhu W., Sano H., Nagai R., Fukuhara K., Miyazaki A., Horiuchi S: The Role of Galectin-3 in endocytosis of advanced glycation end products and modified low density lipoproteins. Biochem. Biophys. Res. Commun. 280, 1183-1188 2001

(4) Sakata N., Uesugi N., Takebayashi S., Nagai R., Jono T., Horiuchi S., Takeya M., Itabe H., Takano T., Myint T., Taniguchi N: Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis. Cardiovasc. Res. 49, 466-475 2001

(5) Ohgami N., Nagai R., Miyazaki A., Ikemoto M., Arai H., Horiuchi S., Nakayama H: Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. J. Biol. Chem. 276, 13348-13355 2001

(6) Kato S., Nakashima K., Horiuchi S., Nagai R., Cleveland DW., Liu J., Hirano A., Takikawa M., Kato M., Nakano I., Sakoda S., Asayama K., Ohama E: Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation. Neuropathology 21, 67-81 2001

(7) Meng J., Sakata, N., Imanaga Y., Takebayashi S., Nagai R., Horiuchi S: Carboxymethyllysine in dermal tissues of diabetic and non-diabetic patients with chronic renal failure: relevance to glycoxidation damage. Nephron 88, 30-35 2001

(8) Ling X., Nagai R., Sakashita N., Takeya M., Horiuchi S., Takahashi K: Immunohistochemical distribution and quantitative biochemical detection of advanced glycation end products in fetal to adult rats and in rats with streptozotocin-induced diabetes. Lab. Invest. 81, 845-861 2001

(9) Shibata N., Nagai R., Uchida K., Horiuchi S., Yamada S., Hirano A., Kawaguchi M., Yamamoto T., Sasaki S., Kobayashi M: Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients. Brain Res. 26, 97-104 2001

(10) Uesugi N., Sakata N., Horiuchi S., Nagai R., Takeya M., Meng J., Saito T., Takebayashi S.. Glycoxidation-modified macrophages and lipid peroxidation products are associated with the progression of human diabetic nephropathy. Am J Kidney Dis. 38, 1016-1025 2001

(11) Kaji Y., Amano S., Usui T., Suzuki K., Tanaka S., Oshika T., Nagai R., Horiuchi S. Advanced glycation end products in Descemet’s membrane and their effect on corneal endothelial cell. Curr Eye Res. 23, 469-477, 2001

(12) Kaji Y., Amano S., Usui T., Suzuki K., Tanaka S., Oshika T., Nagai R., Horiuchi S. Advanced glycation end products in Descemet’s membrane and their effect on corneal endothelial cell. Curr Eye Res. 23, 469-477, 2001

(13) Jono T., Miyazaki A., Nagai R., Sawamura T., Kitamura T., Horiuchi S. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS Lett 511, 170-174 2002

(14) Jono T., Miyazaki A., Nagai R., Sawamura T., Kitamura T., Horiuchi S. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). FEBS Lett 511, 170-174 2002

(15) Hayashi CM., Nagai R., Miyazaki K., Hayase F., Araki T., Ono T., Horiuchi S.. Conversion of Amadori Products of the Maillard Reaction to Ne-(carboxymethyl)lysine by Short-Term Heating: Possible Detection of Artifacts by Immunohistochemistry. Lab Invest. 82, 795-808, 2002

(16) Shibata N., Hirano A., Hedley-Whyte ET., Dal Canto MC., Nagai R., Uchida K., Horiuchi S., Kawaguchi M., Yamamoto T., Kobayashi M. Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation. Acta Neuropathol 104, 171-178, 2002

(17) Nagai R., Unno Y., Hayashi MC., Masuda S., Hayase F., Kinae N., Horiuchi S: Peroxynitrite Induces Formation of Ne-(carboxymethyl)lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal from Glucose: Novel Pathways for Protein Modification by Peroxynitrite, Diabetes. 51, 2833-2839 2002

(18) Tsuru M., Nagata K., Jimi A., Irie K., Yamada A., Nagai R., Horiuchi S., Sata M: Effect of AGEs on human disc herniation: intervertebral disc hernia is also effected by AGEs. Kurume Med J. 49, 7-13 2002

(19) Miyazaki K., Nagai R., Horiuchi S: Creatine plays a direct role as a protein modifier in the formation of a novel advanced glycation end product. J Biochem (Tokyo). 132, 543-550 2002

(20) Nagai R., Hayashi CM., Xia L., Takeya M., Horiuchi S: Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins. J Biol Chem. 277, 48905-48912 2002

(21) Hansen B., Svistounov D., Olsen R., Nagai R, Horiuchi S, Smedsrod B: Advanced glycation end products impair the scavenger function of rat hepatic sinusoidal endothelial cells. Diabetologia. 45, 1379-1388 2002

(22) Jono T., Kimura T., Takamatsu J., Nagai R., Miyazaki K., Yuzuriha T., Kitamura T., Horiuchi S: Accumulation of imidazolone, pentosidine and Ne-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brain. Pathol Int. 52, 563-571 2002

(23) Matsunaga N., Anan I., Forsgren S., Nagai R., Rosenberg P., Horiuchi S., Ando Y., Suhr OB. Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kB activation. Acta Neuropathol (Berl). 104, 441-447 2002

(1) Sakata N., Imanaga Y., Meng J., Tachikawa Y., Takebayashi S., Nagai R., Horiuchi S: Increased advanced glycation end products in atherosclerotic lesions of patients with end-stage renal disease. Atherosclerosis 142, 67-77 1999

(2) Shibata N., Hirano A., Kato S., Nagai R., Horiuchi S., Komori T., Umahara T., Asayama K., Kobayashi M: Advanced glycation endproducts are deposited in neuronal hyaline inclusions: a study on familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation. Acta Neuropathol. 97, 240-246 1999

(3) Ando K., Beppu M., kikugawa K., Nagai R., Horiuchi S: Membrane proteins of human erythrocytes are modified by advanced glycation end products (AGEs) during aging in the circulation. Biochem. Biophys. Res. Commun. 258, 123-127 1999

(4) Honda K., Nitta K., Horita S., Yumura W., Nihei H., Nagai R., Ikeda K., Horiuchi S: Accumulation of advanced glycation end products in the peritoneal vasculature of continuous ambulatory peritoneal dialysis patients with low ultra-filtration. Nephrol Dial. Transplant. 14, 1541-1549 1999

(5) Tajima K., Kawanami T., Nagai R., Horiuchi S: Hereditary ceruloplasminemia deficiency increases advanced glycation end products in the brain. Neurology 53, 619-622 1999

(6) Shibayama R., Araki N., Nagai R., Horiuchi S., Autoantibody against Ne-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction. Diabetes 48, 1842-1849 1999

(7) Kaji Y., Usui T., Oshika T., Matsubara M., Yamashita H., Araie M., Murata T., Ishibashi T., Nagai R., Horiuchi S, Amano S: Advanced glycation end products in diabetic corneas. Invest Ophthalmol Vis. Sci. 41, 362-368 2000

(8) Uesugi N., Sakata N., Nagai R., Jono T., Horiuchi S., Takebayashi S: Glycoxidative modification of AA amyloid deposits in renal tissue. Nephrol. Dial. Transplant. 15, 355-365 2000

(9) Nyhlin N., Ando Y., Nagai R., Suhr O., Sahly M EL., Terazaki H., Yamashita T., Ando M., Horiuchi S: Advanced glycation end product in familial amyloidotic polyneuropathy (FAP). J. Int. Med. 247, 485-492 2000

(10) Imanaga Y., Sakata N., Takebayashi S., Matsunaga A., Sasaki J, Arakawa K., Nagai R., Horiuchi S, Itabe H., Takano T: In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques. Atherosclerosis 150, 343-355 2000

(11) Shibata N., Nagai R., Miyata S., Jono T., Horiuchi S., Hirano A., Kato S., Sasaki S., Asayama K., Kobayashi M: Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation. Acta Neuropathol. 100, 275-284 2000

(12) Nagai R., Matsumoto K., Ling X., Suzuki H., Araki T., Horiuchi S: Glycolaldehyde, a reactive intermediate for advanced glycation endproducts, plays an important role in the generation of an active ligand for the macrophage scavenger receptor. Diabetes 49, 1714-1723, 2000

(13) Hamada Y., Nakamura J., Naruse K., Komori T., Kato K., Kasuya Y., Nagai R., Horiuchi S., Hotta N: Epalrestat, an aldose reductase ihibitor, reduces the levels of Ne-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients. Diabetes Care 23, 1539-1544, 2000

(14) Kato S., Horiuchi S., Shibata N., Cleveland DW., Nagashima K., Nagai R., Hirano A., Takikawa M., Kato M., Nakano I., Ohama E: Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral Sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with G85R mutation. Acta Neuropathol. 100, 490-505 2000

(15) Matsumoto K., Sano H., Nagai R., Suzuki H., Kodama T., Yoshida M., Ueda S., Smedsrød B., Horiuchi S: Endocytic uptake of advanced glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor distinct from the macrophage scavenger receptor-A (MSR-A). Biochem. J. 352, 233-240 2000

(16) Sakata N., Sasatomi Y., Meng .J, Ando S., Uesugi N., Takebayashi S., Nagai R., and Horiuchi S: Possible involvement of altered RGD sequence in reduced adhesive and spreading activities of advanced glycation end product-modified fibronectin to vascular smooth muscle cells. Connect. Tissue Res. 41, 213-218 2000

(1) Nagai R., Ikeda K., Higashi T., Sano H., Jinnouchi Y., Araki T., Horiuchi S: Hydroxyl radical mediates Ne-(carboxymethyl)lysine formation from Amadori product. Biochem. Biophys. Res. Commun. 234, 167-172 1997

(2) Murata T., Nagai R., Ishibashi T., Inomuta H., Ikeda K., Horiuchi S: The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas. Diabetologia, 40, 764-769 1997

(3) Nagai R., Ikeda K., Kawasaki Y., Sano H., Yoshida M., Araki T., Ueda S., Horiuchi S: Conversion of Amadori product of Maillard reaction to Ne-(carboxymethyl)lysine in alkaline condition. FEBS Lett. 425, 355-360 1998

(4) Meng J., Sakata N., Takebayashi S., Asano T., Futata T., Nagai R., Ikeda K., Horiuchi S., Myint T., Taniguchi N: Glycoxidation in aortic collagen from STZ-induced diabetic rats and its relevance to vascular damage. Atherosclerosis 136, 355-365 1998

(5) Jinnouchi Y., Sano H., Nagai R., Hakamata H., Kodama T., Suzuki H., Yoshida M., Ueda S., Horiuchi S: Glycolaldehyde-modified low density lipoprotein leads macrophages to foam cells via the macrophage scavenger receptor. J. Biochem. 123, 1208-1217 1998

(6) Ikeda K., Nagai R., Sakamoto T., Sano H., Araki T., Sakata N., Nakayama H., Yoshida M., Ueda S., Horiuchi S: Immunochemical approaches to AGE-structures: characterization of anti-AGE antibodies. J. Immunol. Methods 215, 95-104 1998

(7) Matsuse T., Ohga E., Teramoto S., Fukayama M., Nagai R., Horiuchi S., Ouchi Y: Immunohistochemical localization of advanced glycation end products in pulmonary fibrosis. J. Clin. Pathol. 51, 515-519 1998

(8) Sakata N., Imanaga Y., Meng J., Tachikawa Y., Takebayashi S., Nagai R., Horiuchi S., Itabe H., Takano T: Immunohistochemical localization of different epitopes of advanced glycation end products in human atherosclerotic lesions. Atherosclerosis 141, 61-75 1998

(9) Ishibashi T., Murata T., Hangai M., Nagai R., Horiuchi S., Lopez PF., Hinton DR., ryan SJ: Advanced glycation end products in age-related macular degeneration. Arch Ophthalmol. 116, 1629-1632 1998

(10) Ling X., Sakashita N., Takeya M., Nagai R., Horiuchi S., Takahashi K: Immunohistochemical distribution and subcellular localization of three distinct specific molecular structures of advanced glycation end products in human tissues. Lab. Invest. 78, 1591-1606 1998