業績

2023年

  • Sakurai T, Kusama K, Imakawa K.Imakawa K.
    Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle.
    Biomolecules. 2023 Nov 21;13(12):1680. doi: 10.3390/biom13121680.

  • Inenaga T, Fukuoka K, Sumida M, Aiba S, Nishikaku K, Matsuno Y, Kobayashi T, Imakawa K.
    Low proviral load in the Kumamoto strain of Japanese Brown cattle infected with the bovine leukemia virus.
    BMC Vet Res. 2023 Oct 2;19(1):185. doi: 10.1186/s12917-023-03738-6.

  • Nakamura K, Kusama K, Hori M,Imakawa K.
    Global analyses and potential effects of extracellular vesicles on the establishment of conceptus implantation during the peri-implantation period.
    J Reprod Dev. 2023 Jul 25. doi: 10.1262/jrd.2023-044.

  • Bai R, Kusama K, Matsuno Y, Bai H, Sakurai T, Kimura K, Imakawa K.
    Expression of NFIL3 and CEBPA regulated by IFNT induced-PGE2 in bovine endometrial stromal cells during the pre-implantation period.
    Front Endocrinol (Lausanne). 2023 Feb 21;14:1075030. doi: 10.3389/fendo.2023.1075030.

2022年

  • Hossain MB, Kobayashi T, Makimoto S, Matsuo M, Nishikaku K, Tan BJY, Rahman A, Rajib SA, Sugata K, Ohnuki N, Saito M, Inenaga T, Imakawa K, Satou Y.
    Clone Dynamics and Its Application for the Diagnosis of Enzootic Bovine Leukosis.
    J Virol. 2022 Dec 19:e0154222. doi: 10.1128/jvi.01542-22.

  • Sharawy HA, Hegab AO, Risha EF, El-Adl M, Soliman WT, Gohar MA, Fahmy RA, Farag VM, Imakawa K, Bazer FW, James D, Zaghloul A, Abdalla AA, Rabie MM, Elmetwally MA.
    The vaginal and uterine blood flow changes during the ovsynch program and its impact on the pregnancy rates in Holstein dairy cows.
    BMC Vet Res. 2022 Sep 17;18(1):350. doi: 10.1186/s12917-022-03444-9.

  • Imakawa K, Kusama K, Kaneko-Ishino T, Nakagawa S, Kitao K, Miyazawa T, Ishino F.
    Endogenous Retroviruses and Placental Evolution, Development, and Diversity.
    Cells. 2022 Aug 8;11(15):2458. doi: 10.3390/cells11152458.

  • Imakawa K, Matsuno Y, Fujiwara H.
    New Roles for EVs, miRNA and lncRNA in Bovine Embryo Implantation.
    Front Vet Sci. 2022 Jul 15;9:944370. doi: 10.3389/fvets.2022.944370.

  • Bai H, Kawahara M, Takahashi M, Imakawa K.
    Recent progress of interferon-tau research and potential direction beyond pregnancy recognition.
    J Reprod Dev. 2022 Jul 23. doi: 10.1262/jrd.2022-061.

  • Nishikaku K, Yonezawa T, Nishibori M, Harada M, Kawaguchi F, Sasazaki S, Torii Y, Imakawa K, Kawai K, Liu J, Mannen H, Kobayashi T.
    Phylogenomics and Spatiotemporal Dynamics of Bovine Leukemia Virus Focusing on Asian Native Cattle: Insights Into the Early Origin and Global Dissemination.
    Front Microbiol. 2022 Jun 24;13:917324. doi: 10.3389/fmicb.2022.917324.

  • Rashid MB, Marey MA, Fukuda K, Haneda S, Kusama K, Shimada M, Imakawa K, Miyamoto A.
    Intrauterine infusion of low levels of interferon-tau on day-8 post-estrus stimulates the bovine endometrium to secrete apolipoprotein-A1: A possible implication for early embryo tolerance.
    Am J Reprod Immunol. 2022 Jul 4:e13592. doi: 10.1111/aji.13592.

  • Oghbaei F, Zarezadeh R, Jafari-Gharabaghlou D, Ranjbar M, Nouri M, Fattahi A,Imakawa K.
    Epithelial-mesenchymal transition process during embryo implantation.
    Cell Tissue Res. 2022 Apr;388(1):1-17. doi: 10.1007/s00441-021-03574-w.

  • Yamada A, Ohtsuki K, Shiga N, Green JA, Matsuno Y, Imakawa K.
    Epithelial-mesenchymal transition and bi- and multi-nucleated trophoblast cell formation in ovine conceptuses during the peri-implantation period.
    J Reprod Dev. 2022 Apr1;68(2):110-117. doi: 10.1262/jrd.2021-088.

  • Matsuno Y, Kusama K, Imakawa K. Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period.
    Biochem Biophys Res Commun. 2022 Feb 26;594:22-30. doi: 10.1016/j.bbrc.2022.01.064.

  • Kusama K, Bai R, Matsuno Y, Ideta A, Sakurai T, Nagaoka K, Hori M, Imakawa K.
    Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers.
    Life (Basel). 2022 Feb18;12(2):309. doi: 10.3390/life12020309.

2021年

  • Nakamura K, Kusama K, Hori M, Imakawa K.
    The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period.
    Biochem Biophys Res Commun. 2021 Oct 8;573:100-106. doi:10.1016/j.bbrc.2021.08.019.

  • Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M,Khatib H, Imakawa K, Miyamoto A.
    Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions.
    Front Genet. 2021 Jun 28;12:676791. doi:10.3389/fgene.2021.676791.

  • Fiorenza MF, Marey MA, Rashid MB, Zinnah MA, Ma D, Morillo VA, Kusama K,Shimada M, Imakawa K, Antoniazzi AQ, Miyamoto A.
    Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.
    Biochem Biophys Res Commun. 2021 May 14;553:37-43. doi:10.1016/j.bbrc.2021.03.037.

  • Matsuno Y, Kusama K, Amin YA, Imakawa K. (2021) Formation of fibrin at sights of conceptus adhesion in the ewe. Reproduction 161(6):709-720. doi: 10.1530/REP-20-0531.

  • Ohnuki N, Kobayashi T, Matsuo M, Nishikaku K, Kusama K, Torii Y, Inagaki Y, Hori M, Imakawa K, Satou Y. (2021) A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP. Sci Rep. 11(1):4521. doi: 10.1038/s41598-021-83909-3.

2020年

  • Inagaki Y, Kobayashi T, Suda Y, Kusama K, Imakawa K. (2020) Genetic variation in Japanese Holstein cattle for EBL development. BMC Vet Res. 16(1):407. doi: 10.1186/s12917-020-02625-8.

  • Zinnah MA, Marey MA, Akhtar I, Elesh IF, Matsuno Y, Elweza AE, Ma D, Fiorenza M, Sasaki M, Shimada M, Imakawa K, Miyamoto A (2020) Peptidoglycan disrupts early embryo-maternal crosstalk via suppression of ISGs expression induced by interferon-tau in the bovine endometrium. Biochem Biophys Res Commun. 532(1):101-107. doi: 10.1016/j.bbrc.2020.08.006.

  • Marey MA, Aboul Ezz M, Akthar I, Yousef MS, Imakawa K, Shimada M, Miyamoto A. (2020) Sensing sperm via maternal immune system: a potential mechanism for controlling microenvironment for fertility in the cow. J Anim Sci. 98(Suppl 1):S88-S95. doi: 10.1093/jas/skaa147.

  • Otsuki K, Nakagawa S, Imakawa K. (2020) Retrotransposons on the development and divetsity of placenta. J. Mamm. Ova Res. Vol.37(2),95-106, 2020

  • Nakamura K, Kusama K, Suda Y, Fujiwara H, Hori M, Imakawa K. (2020) Emerging Role of Extracellular Vesicles in Embryo-Maternal Communication throughout Implantation Processes. Int J Mol Sci. 21(15):5523. doi: 10.3390/ijms21155523.

  • Nakamura K, Kusama K, Ideta A, Imakawa K, Hori M. (2020) IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle. Reproduction. 159(5):503-511. doi: 10.1530/REP-19-0314.

2019年

  • ・Talukder AK, Rashid MB, Takedomi T, Moriyasu S, Imakawa K, Miyamoto A.Day-7 embryos generate an anti-inflammatory immune response in peripheral blood immune cells in superovulated cows.Am J Reprod Immunol. 2019 Feb;81:e13069. doi: 10.1111/aji.13069. Epub 2018 Nov 9.　PMID: 30376193
  • ・Choi SA, Kim YH, Park YH, Yang HJ, Jeong PS, Cha JJ, Yoon SB, Kim JS, Song BS, Lee JH, Sim BW, Huh JW, Song IS, Lee SR, Kim MK, Kim JM, Bae YS, Imakawa K, Kim SU, Chang KT.Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.　Cell Death Differ. 2018 Nov 21. doi: 10.1038/s41418-018-0226-0.　　　PMID: 30464227

    ・Fujiwara H, Matsumoto H, Sato Y, Horie A, Ono M, Nakamura M, Mizumoto Y, Kagami K, Fujiwara T, Hattori A, Maida Y, Daikoku T, Imakawa K, Araki Y.Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems.Curr Pharm Biotechnol. 2018;19:764-770. doi: 10.2174/1389201019666181029164906. Review.　PMID: 30378495

    ・Talukder AK, Rashid MB, Yousef MS, Kusama K, Shimizu T, Shimada M, Suarez SS, Imakawa K, Miyamoto A.Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells.Sci Rep. 2018 May 18;8:7850. doi: 10.1038/s41598-018-26224-8.　PMID: 29777205

    ・Kusama K, Tamura K, Bai H, Sakurai T, Nishi H, Isaka K, Imakawa K, Yoshie M.Exchange protein directly activated by cAMP (EPAC) promotes transcriptional activation of the decidual prolactin gene via CCAAT/enhancer-binding protein in human endometrial stromal cells．Reprod Fertil Dev. 2018 May 8. doi: 10.1071/RD17483. [Epub ahead of print]　　PMID: 29735004

    ・Rashid MB, Talukder AK, Kusama K, Haneda S, Takedomi T, Yoshino H, Moriyasu S, Matsui M, Shimada M, Imakawa K, Miyamoto A.Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus.Biochem Biophys Res Commun. 2018 Jun 12;500:879-884. doi: 10.1016/j.bbrc.2018.04.178. Epub 2018 Apr 30.　　PMID: 29702095

    ・Imakawa K, Bai R, Kusama K.Integration of molecules to construct the processes of conceptus implantation to the maternal endometrium.J Anim Sci. 2018 Jun 29;96:3009-3021. doi: 10.1093/jas/sky103. Review.　PMID: 29554266

    ・Kim MS, Min KS, Seong HH, Kim CL, Jeon IS, Kim SW, Imakawa K.Regulation of conceptus interferon-tau gene subtypes expressed in the uterus during the peri-implantation period of cattle.Anim Reprod Sci. 2018 Mar;190:39-46. doi: 10.1016/j.anireprosci.2018.01.005. Epub 2018 Feb 3.　PMID: 29402638

    ・Bai R, Kusama K, Nakamura K, Sakurai T, Kimura K, Ideta A, Aoyagi Y, Imakawa K.Down-regulation of transcription factor OVOL2 contributes to epithelial-mesenchymal transition in a noninvasive type of trophoblast implantation to the maternal endometrium.FASEB J. 2018 Jun;3:3371-3384. doi: 10.1096/fj.201701131RR. Epub 2018 Feb 2.　PMID: 29394105

    ・Kusama K, Bai R, Imakawa K.Regulation of human trophoblast cell syncytialization by transcription factors STAT5B and NR4A3.J Cell Biochem. 2018 Jun;119:4918-4927. doi: 10.1002/jcb.26721. Epub 2018 Mar 7.　PMID: 29377304

    ・Elweza AE, Ezz MA, Acosta TJ, Talukder AK, Shimizu T, Hayakawa H, Shimada M, Imakawa K, Zaghloul AH, Miyamoto A.A proinflammatory response of bovine endometrial epithelial cells to active sperm in vitro.Mol Reprod Dev. 2018 Mar;85:215-226. doi: 10.1002/mrd.22955. Epub 2018 Feb 13.　PMID: 29337420

    ・Kusama K, Nakamura K, Bai R, Nagaoka K, Sakurai T, Imakawa K.Intrauterine exosomes are required for bovine conceptus implantation.Biochem Biophys Res Commun. 2018 Jan 1;495:1370-1375. doi: 10.1016/j.bbrc.2017.11.176. Epub 2017 Nov 28.　PMID: 29196267

    ・Bai R, Latifi Z, Kusama K, Nakamura K, Shimada M,Imakawa K.Induction of immune-related gene expression by seminal exosomes in the porcine endometrium.
    Biochem Biophys Res Commun. 2018 Jan 1;495:1094-1101. doi: 10.1016/j.bbrc.2017.11.100. Epub 2017 Nov 17.　PMID: 29155178

    ・Latifi Z, Fattahi A, Ranjbaran A, Nejabati HR, Imakawa K.Potential roles of metalloproteinases of endometrium-derived exosomes in embryo-maternal crosstalk during implantation.
    J Cell Physiol. 2018 Jun;233:4530-4545. doi: 10.1002/jcp.26259. Epub 2017 Dec 26. Review.　PMID: 29115666

2017年

  •  
  • Ezashi T, Imakawa K. Transcriptional control of IFNT expression. Reproduction. 2017 154:F21-F31. PMID: 28982936 Review
  • Sakurai T, Nakagawa S, Bai H, Bai R, Kusama K, Ideta A, Aoyagi Y, Kaneko K, Iga K, Yasuda J, Miyazawa T, Imakawa K. Novel endogenous retrovirus-derived transcript expressed in the bovine placenta is regulated by WNT signaling. Biochem J. 2017 474:3499-3512. PMID: 28899944
  • Matsumoto K, Imakawa K, Hayashi C. Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. BMC Pregnancy Childbirth. 2017 17:312. PMID: 28931393
  • Nakamura K, Kusama K, Bai R, Ishikawa S, Fukushima S, Suda Y, Imakawa K. Increase in complement iC3b is associated with anti-inflammatory cytokine expression during late pregnancy in mice. PLoS One. 2017 12:e0178442. PMID: 28542608
  • Talukder AK, Yousef MS, Rashid MB, Awai K, Acosta TJ, Shimizu T, Okuda K, Shimada M, Imakawa K, Miyamoto A. Bovine embryo induces anti-inflammatory response in uterine epithelial cells and immune cells in vitro: Possible involvement of IFNT as an intermediator. J Reprod Dev. 2017 63:425-434. PMID: 28603222
  • Imakawa K, Bai R, Nakamura K, Kusama K. Thirty years of interferon-tau research; Past, present and future perspective. Anim Sci J. 2017 88:927-936.
    PMID: 28504476 Review
  • Shirozu T, Iwano H, Ogiso T, Suzuki T, Balboula AZ, Bai H, Kawahara M, Kimura K, Takahashi H, Rulan B, Kim SW, Yanagawa Y, Nagano M, Imakawa K, Takahashi M. Estrous cycle stage-dependent manner of type I interferon-stimulated genes induction in the bovine endometrium. J Reprod Dev. 2017 63:211-220. PMID: 28239027
  • Imakawa K, Bai R, Fujiwara H, Ideta A, Aoyagi Y, Kusama K. Continuous model of conceptus implantation to the maternal endometrium. J Endocrinol. 2017 233:R53-R65. PMID: 28213399 Review
  • Kusama K, Bai R, Nakamura K, Okada S, Yasuda J, Imakawa K. Endometrial factors similarly induced by IFNT2 and IFNTc1 through transcription factor FOXS1. PLoS One. 2017 12:e0171858. PMID: 28199372
  • Imakawa K, Nakagawa S. The Phylogeny of Placental Evolution Through Dynamic Integrations of Retrotransposons. Prog Mol Biol Transl Sci. 2017;145:89-109. PMID: 28110755 Review
  • Haneda S, Nagaoka K, Nambo Y, Kikuchi M, Nakano Y, Li J, Matsui M, Miyake YI, Imakawa K. Expression of uterine lipocalin 2 and its receptor during early- to mid-pregnancy period in mares. J Reprod Dev. 2017 63:127-133. PMID: 27980236
  • 中村圭吾、草間和哉、白　汝嵐、須田義人、今川和彦「妊娠における補体iC3bの新たな胎仔免疫寛容への効果」日本生殖内分泌学会雑誌　2017年 22巻 pp.39-47

2016年

  • Nakamura K, Kusama K, Bai R, Sakurai T, Isuzugawa K, Godkin JD, Suda Y, Imakawa K. Induction of IFNT-Stimulated Genes by Conceptus-Derived Exosomes during the Attachment Period. PLoS One. 2016 11:e0158278. PMID: 27351483
  • Kusama K, Bai R, Ideta A, Aoyagi Y, Okuda K, Imakawa K. Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A. Mol Cell Endocrinol. 2016 434:81-92. PMID: 27321969
  • Kusama K, Bai R, Sakurai T, Bai H, Ideta A, Aoyagi Y, Imakawa K. A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses. Domest Anim Endocrinol. 2016 57:21-30. PMID: 27315596
  • Imakawa K, Dhakal P, Kubota K, Kusama K, Chakraborty D, Karim Rumi MA, J Soares M. CITED2 modulation of trophoblast cell differentiation: insights from global transcriptome analysis. Reproduction. 2016 151:509-516. PMID:26917451
  • Fujiwara H, Araki Y, Imakawa K, Saito S, Daikoku T, Shigeta M, Kanzaki H, Mori T. Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo. Am J Reprod Immunol. 2016 75:281-289. PMID:26755274
  • Imakawa K, Bai R, Fujiwara H, Kusama K. Conceptus implantation and placentation: molecules related to epithelial-mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes. Reprod Med Biol. 2016 15:1-11. Review
  • 今川和彦、中川　草、草間和哉「胎盤と内在性レトロウイルス」ウイルス　2016年 66巻1号 pp.1-10 PMID: 28484172
  • 今川和彦、草間和哉「着床」不妊・不育診療指針　2016年 pp.26-30
  • 草間和哉、今川和彦「着床成立に向けた子宮内環境の構築と再構築」日本胚移植学雑誌　2016年　38巻 pp.123-129

2015年

  • Imakawa K, Nakagawa S, Miyazawa T. Baton pass hypothesis: successive incorporation of unconserved endogenous retroviral genes for placentation during mammalian evolution. Genes Cells. 2015 20:771-788. Review PMID:26442811
  • Yoshie M, Kusama K, Tamura K. Molecular mechanisms of endometrial decidualization activated by cyclic adenosine monophosphate signaling pathway. J Mamm Ova Res. 2015 32:1-8. Review
  • Kusama K, Yoshie M, Tamura K, Imakawa K, Isaka K, Tachikawa E. Regulatory Action of Calcium Ion on Cyclic AMP-Enhanced Expression of Implantation-Related Factors in Human Endometrial Cells. PLoS One. 2015 10:e0132017. PMID:26161798
  • Tamura K, Takashima H, Fumoto K, Kajihara T, Uchino S, Ishihara O, Yoshie M, Kusama K, Tachikawa E. Possible Role of α1-Antitrypsin in Endometriosis-Like Grafts From a Mouse Model of Endometriosis. Reprod Sci. 2015 22:1088-1097. PMID:25667209
  • Bai R, Kusama K, Sakurai T, Bai H, Wang C, Zhang J, Kuse M, Ideta A, Aoyagi Y, Okuda K, Imakawa K. The Role of Endometrial Selectins and Their Ligands on Bovine Conceptus Attachment to the Uterine Epithelium During Peri-Implantation Period. Biol Reprod. 2015 93:46. PMID:26134867
  • Kusama K, Yoshie M, Tamura K, Imakawa K, Tachikawa E. EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells. J Mol Endocrinol. 2015 54:17-24. PMID:25378661
  • 今川和彦、草間和哉「ウシ繁殖成績・受胎率の向上を目指して　インターフェロン・タウの発見とその利用」MPアグロジャーナル　2015年 20巻 pp.17-21
  • 今川和彦、白 汝嵐、草間和哉「遺伝子発現の網羅的解析による胚・胎盤発生の解析」HORMONE FRONTIER GYNECOLOGY 2015年 22巻1号 pp.47-51
  • 吉江幹浩、草間和哉、田村和広、山崎梨沙香、立川英一「ラット子宮間質細胞の脱落膜化におけるCalreticulinの役割」日本生殖内分泌学会雑誌　2015年 20巻 pp.35-40

2014年

  • Tachibana Y, Sakurai T, Bai H, Shiota K, Nambo Y, Nagaoka K, Imakawa K. RNA-seq analysis of equine conceptus transcripts during embryo fixation and capsule disappearance. PLoS One. 2014 9:e114414. PMID:25514169
  • Bai H, Sakurai T, Bai R, Godkin JD,Imakawa K. Localization of GATA2 in the nuclear and cytoplasmic regions of ovine conceptuses. Anim Sci J. 2014c 85:981-985. PMID:25163535
  • Bai R, Bai H, Kuse M, Ideta A, Aoyagi Y, Fujiwara H, Okuda K, Imakawa K, Sakurai T. Involvement of VCAM1 in the bovine conceptus adhesion to the uterine endometrium. Reproduction. 2014 148:119-27. PMID:24803492
  • Bai H, Sakurai T, Bai R, Yamakoshi S, Aoki E, Kuse M, Okuda K, Imakawa K. Establishment and characterization of immortalized bovine endometrial epithelial cells. Anim Sci J. 2014b 85:799-804. PMID:24735401
  • Kusama K, Yoshie M, Tamura K, Daikoku T, Takarada T, Tachikawa E. Possible roles of the cAMP-mediators EPAC and RAP1 in decidualization of rat uterus. Reproduction. 2014 147:897-906. PMID:24586073
  • Kusama K, Yoshie M, Tamura K, Nakayama T, Nishi H, Isaka K, Tachikawa E. The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells. Endocrinology. 2014 155:240-248. PMID:24169561
  • Bai H, Sakurai T, Godkin JD, Imakawa K. Expression and in situ localization of GATA4, 5 and 6 mRNAs in ovine conceptuses and uterine endometria during the peri-implantation period. Anim Sci J. 2014a 85:388-394. PMID:24329758
  • Imakawa K, Kusama K, Yasuda J. Early placentation and local immune regulation. Reproduction in Domestic Ruminants. 2014 8:375-386. Review
  • 今川和彦、白 汝嵐、草間和哉「ウシの繁殖成績向上を目指して：基礎研究から」関東畜産学会報　2014年　64巻2号 pp.17-25
  • 今川和彦、草間和哉「加齢と子宮機能：いかにして着床率をあげるか？」生殖バイオロジー東京シンポジウム会誌　2014年 pp.20-29

2013年

  • Kim MS, Min KS, Imakawa K. Regulation of Interferon-stimulated Gene (ISG)12, ISG15, and MX1 and MX2 by Conceptus Interferons (IFNTs) in Bovine Uterine Epithelial Cells.Asian-Australas J Anim Sci. 2013 26:795-803. PMID:25049852
  • Sakurai T, Nakagawa S, Kim MS, Bai H, Bai R, Li J, Min KS, Ideta A, Aoyagi Y, Imakawa K. Transcriptional regulation of two conceptus interferon tau genes expressed in Japanese black cattle during peri-implantation period. PLoS One. 2013 8:e80427. PMID:24348910
  • Kim MS, Sakurai T, Bai H, Bai R, Sato D, Nagaoka K, Chang KT, Godkin JD, Min KS, Imakawa K. Presence of Transcription Factor OCT4 Limits Interferon-tau Expression during the Pre-attachment Period in Sheep. Asian-Australas J Anim Sci. 2013 26:638-645. PMID:25049833
  • Sakurai T, Bai H, Bai R, Sato D, Arai M, Okuda K, Ideta A, Aoyagi Y, Godkin JD, Imakawa K. Down-regulation of interferon tau gene transcription with a transcription factor, EOMES. Mol Reprod Dev. 2013 80:371-383.PMID:23606646
  • Bai H, Sakurai T, Godkin JD,Imakawa K. Expression and potential role of GATA factors in trophoblast development. J Reprod Dev. 2013 59:1-6. Review PMID:23428586
  • Kusama K, Yoshie M, Tamura K, Kodaka Y, Hirata A, Sakurai T, Bai H, Imakawa K, Nishi H, Isaka K, Nagai T, Nagao T, Tachikawa E. Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac). Placenta. 2013 34:212-221. PMID:23352189
  • Nakagawa S, Bai H, Sakurai T, Nakaya Y, Konno T, Miyazawa T, Gojobori T, Imakawa K. Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentation. Genome Biol Evol. 2013 5:296-306. PMID:23335121
  • Tachibana Y, Nakano Y, Nagaoka K, Kikuchi M, Nambo Y, Haneda S, Matsui M, Miyake Y, Imakawa K. Expression of endometrial immune-related genes possibly functioning during early pregnancy in the mare.J Reprod Dev. 2013 59:85-91. PMID:23138119
  • Zhang H, Nagaoka K,Imakawa K, Nambo Y, Watanabe G, Taya K, Weng Q. Expression of inhibin/activin subunits in the equine uteri during the early pregnancy. Reprod Domest Anim. 2013 48:423-438. PMID:23043254

2012年

  • Chaen T, Konno T, Egashira M, Bai R, Nomura N, Nomura S, Hirota Y, Sakurai T, Imakawa K. Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012 7:e48933. PMID:23152823
  • Tachibana Y, Nakano Y, Nagaoka K, Kikuchi M, Nambo Y, Haneda S, Matsui M, Miyake Y, Imakawa K. Expression of endometrial immune-related genes possibly functioning during early pregnancy in the mare. J Reprod Dev. 2013 59:85-91. PMID:23138119
  • Sakurai T, Bai H, Bai R, Arai M, Iwazawa M, Zhang J, Konno T, Godkin JD, Okuda K, Imakawa K. Coculture system that mimics in vivo attachment processes in bovine trophoblast cells. Biol Reprod. 2012 87:60. PMID:22723465
  • Nakaya Y, Shimode S, Kobayashi T, Imakawa K, Miyazawa T. Binding of transcription factor activating protein 2 γ on the 5'-proximal promoter region of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B. Xenotransplantation. 2012 19:177-185. PMID:22702469
  • Yamakoshi S, Bai R, Chaen T, Ideta A, Aoyagi Y, Sakurai T, Konno T, Imakawa K. Expression of mesenchymal-related genes by the bovine trophectoderm following conceptus attachment to the endometrial epithelium.Reproduction. 2012 143:377-387. PMID:22157247
  • Bai H, Sakurai T, Konno T, Ideta A, Aoyagi Y, Godkin JD,Imakawa K. Expression of GATA1 in the ovine conceptus and endometrium during the peri-attachment period. Mol Reprod Dev. 2012 79:64-73. PMID:22102538

2011年

  • Bai H, Sakurai T, Someya Y, Konno T, Ideta A, Aoyagi Y, Imakawa K. Regulation of trophoblast-specific factors by GATA2 and GATA3 in bovine trophoblast CT-1 cells.J Reprod Dev. 2011 57:518-525. PMID:21606631
  • Park SJ, Huh JW, Kim YH, Kim JS, Song BS, Lee SR, Kim SU, Kim HS, Imakawa K, Chang KT. Quantitative analysis of retromer complex-related genes during embryo development in the mouse. Mol Cells. 2011 31:431-436. PMID:21359680
  • Kikuchi M, Nakano Y, Nambo Y, Haneda S, Matsui M, Miyake Y, Macleod JN, Nagaoka K, Imakawa K. Production of calcium maintenance factor Stanniocalcin-1 (STC1) by the equine endometrium during the early pregnant period. JReprod Dev. 2011 57:203-211. PMID:21139325
  • Baba K, Nakaya Y, Shojima T, Muroi Y, Kizaki K, Hashizume K, Imakawa K, Miyazawa T. Identification of novel endogenous betaretroviruses which are transcribed in the bovine placenta. J Virol. 2011 85:1237-1245. PMID:21084469
  • Nakaya Y, Shojima T, Yasuda J, Imakawa K, Miyazawa T. Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B. Microbes Infect. 2011 13:49-57. PMID:20951222

2010年

  • Sakai S, Satow T,Imakawa K, Nagaoka K. Hydrogen peroxide produced by a low-molecular-weight compound in milk with high electrical conductivity in dairy cows. Anim Sci J. 2010 81:694-698. PMID:21108690
  • Ideta A, Hayama K, Nakamura Y, Sakurai T, Tsuchiya K, Tanaka S, Yamaguchi T, Fujiwara H, Imakawa K, Aoyagi Y. Intrauterine administration of peripheral blood mononuclear cells enhances early development of the pre-implantation bovine embryo.Mol Reprod Dev. 2010 77:954-962. PMID:21104766
  • Sakurai T, Bai H, Konno T, Ideta A, Aoyagi Y, Godkin JD, Imakawa K. Function of a transcription factor CDX2 beyond its trophectoderm lineage specification. Endocrinology. 2010 151:5873-5881. PMID:20962045
  • Yoshie M, Kaneyama K, Kusama K, Higuma C, Nishi H, Isaka K, Tamura K. Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells. Hum Reprod. 2010 25:2229-2238. PMID:20663796